Job Description

Principal Scientist Analytical Chemistry

Diasome Pharmaceuticals, Inc. is focused on the clinical and commercial development of breakthrough therapies for diabetes and obesity. Based on more than thirty years of research and development in the fields of cell receptor targeting, insulin replacement, and hepatic (liver) glucose metabolism, the Company’s pipeline includes multiple injected and oral formulations of liver targeted insulins for both Type 1 and Type 2 diabetic patients that are Phase 3 ready. In addition, we are developing a first-in-class oral compound for the Type 2 diabetes population that is based upon new insights into normal glucose metabolism and a novel mechanism of action, along with a nanotechnology-based oral compound that may have a significant impact in treating obesity.

Job Description

We seek a highly motivated Analytical Chemist with extensive experience in a wide range of analytical techniques, including HPLC, LC/MS, MALS, DLS, particle size analysis, UV/VIS, and ELISA. The candidate will lead our Analytical Chemistry team, and will be responsible for the research, development, and implementation of analytical methods to analyze Diasome’s novel liver targeting drug delivery systems and associated drug substances. In addition, the candidate will lead the effort to transfer developed analytical methods to external cGMP houses.

You will report to the Chief Technology Officer.

Specific Responsibilities:

  • Lead the analytical chemistry and analytical methods development efforts, supervise the analytical chemistry staff, and ensure smooth operation of the group.
  • Identify all analytical testing needs, and implement the most cost-effective means of meeting them, both through internal and external resources.
  • Assist in the justification/preparation of the departmental budget to meet current and future equipment, facility, and staff requirements.
  • Support the analysis of raw materials, stability study samples, finished products, etc., by HPLC, LC/MS, MALS, DLS, particle size analysis, UV/VIS, ELISA, and other techniques as needed.
  • Develop and implement new analytical methods as required.
  • Ensure that specifications, sampling plans, procedures and test methods are accurate, valid, and functional and, when necessary, initiate change.
  • Ensure that training programs are developed, maintained, and effective in keeping employees updated in inspection and test methods, and industry-accepted practices.
  • Maintain and troubleshoot problems with analytical instruments.
  • Interact closely with the Formulations and Conjugate Chemistry teams.

Ideal Candidate Possesses:

  • MS/PhD in analytical chemistry or a related discipline.
  • 5+ years of experience.
  • Extensive experience with HPLC, LC/MS, MALS, DLS, particle size analysis, UV/VIS, ELISA, and the development and implementation of analytical methods.
  • Must be able to work in a fast paced environment with the ability to work on multiple projects.
  • The candidate will be self-motivated, able to think and work independently, while contributing to a team effort to achieve business and technical objectives.
  • The following experience, although not required, would certainly add to a candidate’s chances of success:
    • (Bio)pharmaceutical industrial environment
    • Synthetic organic chemistry
    • Chemistry and analysis of phospholipids
    • PhD

Location and Compensation: Cleveland, OH. Competitive biotech industry package.

Required experience: HPLC, LC/MS, MALS, DLS, particle size analysis, UV/VIS, ELISA analytical methods development, implementation, qualification, and validation within a GLP/cGMP environment: 5 years.

Required education: Masters.


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