July 22, 2016
Conversations on Protein Structure and Function (PHOL 456) Fall 2016
15 sessions at 2 credits
(to be taken primarily by SBB-TP students,
and others with background in physical-chemical sciences and strong interest in protein structure and
biophysics by permission)
The goal of this course is to provide an in-depth introduction of research areas and discussion on
current topics for students with backgrounds in physical-chemical sciences and/or to students who
already have a good basic background in protein science.
The course presents a overview of Protein structure/function. Following an introduction to/revision
of the principles of protein structure, the physical basis of protein folding and stability, and a brief
overview of structural and bioinformatics approaches to protein analysis is presented. Typically two
lecture/discussion style presentations are followed by a student lead journal club on recent high
profile papers. The way the Journal club is done is that one student presents a paper (background and
figures in powerpoint slides) while presentation of the main figures is shared between the class.
Papers and Figures will be assigned by instructor. Typically two papers will be presented per session.
Student presentations 40%
In class exercises/participation 30%
Final exam 30%
“How Proteins work” by Mike Williamson, Garland Science
Course Director: Matthias Buck
Matthias Buck (MB), Sudha Chaprakani (SC), Masaru Miyagi (MM), Witold Surewicz (WS), Sichun